Estro Basic Clinical Radiobiology Course

Toledo del 18 al 23 de Octubre de 2009

STRO Basic Clinical Radiobiology course

COURSE DIRECTOR: A. VAN DER KOGEL (NL)
TEACHING STAFF: W. DÖRR (D), V. GRÉGOIRE (B), M. JOINER (USA),
M. KORITZINSKY (CA), M., NORDSMARK (DK)

SAT- 17 OCTOBER

Arrival and registration (17.00-19.00)

SUN- 18 OCTOBER

09.00-09.20 Introduction – A. van der Kogel
09.20-10.00 Importance of radiobiology in the clinic – V. Grégoire
10.00-10.30 Hallmarks of cancer – M. Koritzinsky
10.30-11.00 Coffee
11.00-11.45 Molecular basis of cell death – M. Koritzinsky
11.45-12.15 Cell survival – in vitro and in vivo – A. van der Kogel
12.15-13.00 Models of radiation cell killing – M. Joiner
13.00 – 14.15 Lunch
14.15-14.45 LET and RBE – M. Joiner
14.45-15.30 Clinical side effects and its quantification – M. Nordsmark
15.30-16.00 Coffee
16.00-17.00 Pathogenesis of normal tissue side effects – W. Dörr
Welcome reception

MON- 19 OCTOBER

09.00-09.45 The linear-quadratic approach to fractionation – M. Joiner
09.45-10.30 Molecular basis of radiation response: DNA repair/checkpoints – M. Koritzinsky
10.30-11.00 Coffee
11.00-11.30 Normal tissues: radiosensitivity & fractionation - W. Dörr
11.30-12.30 Normal tissues: overall treatment time - W. Dörr
12.30-13.00 General discussion
13.00-14.00 Lunch
14.00-15.00 Hyperfractionation and accelerated radiotherapy – V. Grégoire
15.00-15.45 The LQ-model in practice –introduction to calculations – M. Joiner
15.45-16.15 Coffee
16.15-17.00 The LQ-model in practice – examples of calculations – M. Joiner

TUE - 20 OCTOBER

09.00-10.00 The oxygen effect – A. van der Kogel
10.00-10.45 Hypoxia and tumor microenvironment – M. Koritzinsky
10.45-11.15 Coffee
11.15-12.00 Clinical efforts to modify tumor hypoxia – M. Nordsmark
12.00-13.00 General discussion/clinical questions
13.00 Lunch
Social tour and dinner

WED – 21 OCTOBER

09.30-10.00 Dose-response relationships in radiotherapy – M. Joiner
10.00-11.00 The volume effect in radiotherapy – W. Dörr
11.00-11.30 Coffee
11.30-12.15 The dose-rate effect – A. van der Kogel
12.15-13.00 General discussion / clinical questions
13.00 -14.00 Lunch
14.00 -14.45 Combined radiotherapy and chemotherapy – V. Grégoire
14.45 -15.30 Retreatment tolerance of normal tissues – W. Dörr
15.30-16.00 Coffee
16.00 -17.30 Clinical examples – volume, retreatment– V. Grégoire / M. Nordsmark

THU – 22 OCTOBER

09.00-09.45 Biological image guided radiotherapy – V. Grégoire
09.45-10.30 Tumor growth and response to irradiation – A. van der Kogel
10.30-11.00 Coffee
11.00-11.45 Radiation-induced malignancies – M. Joiner
11.45-12.30 Biological response modifiers in tumors – preclinical – M. Koritzinsky
12.30-13.00 General discussion / clinical questions
13.00 -14.00 Lunch
14.00-14.45 Biological response modifiers in tumors – clinical – M. Nordsmark
14.45-15.30 Biological modifiers of normal tissue effects – W. Dörr
15.30-16.00 Coffee
16.00-17.30 Clinical cases – V. Grégoire / M. Nordsmark

FRI – 23 OCTOBER

09.00-10.00 Particles in radiotherapy – V. Grégoire
10:00-10.45 Examination
10.45-11.15 Coffee
11.15-11.30 Course evaluation & certificates